A dual-strike strategy against glycolytic and mitochondrial metabolism for potentiated mild photothermal therapy

Key Points

• This research aims to develop a strategy targeting both glycolytic and mitochondrial metabolism to enhance photothermal therapy effectiveness.
• Utilized a mitochondria-targeted photothermal agent.
• Concurrently suppressed glycolysis and disrupted oxidative phosphorylation.
• Measured ATP levels and heat shock protein expression.
• Induced significant ATP depletion.
• Inhibited expression of heat shock proteins.
• Enhanced efficacy of mild photothermal therapy.