Development of novel salicylic acid derivatives with dual anti-inflammatory and anti-arthritic potentials: synthesis, in vitro bio-evaluation, and in silico toxicity prediction with molecular modeling simulations

Key Points

• The study aims to develop and evaluate novel salicylic acid derivatives with potential therapeutic effects against inflammation and arthritis.
• Synthesis of salicylic acid derivatives
• In vitro bio-evaluation of anti-inflammatory and anti-arthritic properties
• In silico modeling for toxicity prediction
• The new derivatives showed significant anti-inflammatory activity in vitro.
• Selected compounds demonstrated anti-arthritic effects in bio-evaluation tests.
• Molecular modeling predicted favorable toxicity profiles for the derivatives.