Abstract Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder associated with insulin resistance and metabolic dysfunction. Elevated serum ferritin levels in PCOS indicate iron overload, which may impair insulin signaling, contributing to hyperinsulinemia and metabolic imbalance. Understanding this relationship could guide improved therapeutic strategies. Aim: to study the correlation of serum ferritin level with insulin resistance in women diagnosed with polycystic ovary syndrome. Result: The study of 65 PCOS patients revealed a mean age of 26.03 ± 5.27 years, predominantly Hindu and urban middle-class. Mean serum ferritin was 52.02 ± 31.22 ng/mL and HOMA-IR 3.25 ± 1.87. A strong positive correlation (r = 0.74, p < 0.0001) was observed between serum ferritin and insulin resistance, indicating significant metabolic association. Method: This prospective study was conducted in the Department of Obstetrics and Gynaecology, SMS Medical College, including women aged 16–40 years diagnosed with PCOS using Rotterdam criteria. Detailed demographic, clinical, and biochemical evaluations were performed. Serum ferritin, fasting insulin, and glucose were measured to calculate HOMA-IR. Correlations between serum ferritin, insulin resistance, and metabolic parameters were statistically analyzed to assess metabolic risk in PCOS. Conclusion: In conclusion, elevated serum ferritin levels are significantly associated with increased insulin resistance in women with PCOS, independent of ovarian morphology or anthropometric factors. Ferritin may serve as a valuable early marker for metabolic dysfunction, aiding in timely identification and management. Larger, multicentric studies are needed to validate these findings.
International Journal of Medical Science and Advanced Clinical Research (IJMACR) (Sun,) studied this question.