The Impact of 5-HTTLPR Polymorphism on Depression and Lymphocyte Changes in Colorectal Cancer Patients Undergoing FOLFOX Chemotherapy

Key Points

• This research explores how the 5-HTTLPR polymorphism influences depression and immune cell changes in colorectal cancer (CRC) patients undergoing treatment.
• Analyzed lymphocyte percentages, specifically CD4+ and CD16/56+ cells, in CRC patients during FOLFOX chemotherapy.
• Assessed the impact of 5-HTTLPR alleles on these immune cell changes under depressive conditions.
• A significant moderation effect of 5-HTTLPR alleles on the percentages of CD4+ and CD16/56+ lymphocytes was observed.
• Findings suggest that depression may alter immune responses depending on genetic factors.