Background Hemoglobin A1c is widely recognized as an indicator of long-term glucose control in patients with diabetes. Its measurement, however, can be influenced by several hemoglobin disorders, including the β-thalassemia trait, which is relatively common in the Middle East. Methods This work compared manual HbA1c testing procedures with an automated high-performance liquid chromatography (HPLC) technique in diabetic patients carrying the β-thalassemia trait. Sixty diagnosed diabetic cases with confirmed β-thalassemia were included from Fallujah Teaching Hospital. HbA1c was analyzed by three procedures: Variant II HPLC, ion-exchange resin, and Turbidimetric immunoassay. Data were processed using ANOVA, t-test, and Pearson correlation in SPSS, considering p 0.82, p
Alheeti et al. (Tue,) studied this question.
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