Longitudinal implications of BDNF rs6265 polymorphism on motor and non-motor features of Parkinson’s disease in Korean population | Synapse
January 22, 2026Open Access
Longitudinal implications of BDNF rs6265 polymorphism on motor and non-motor features of Parkinson’s disease in Korean population
Key Points
This research aims to investigate how the BDNF rs6265 polymorphism affects both motor and non-motor symptoms in individuals with Parkinson's disease.
Longitudinal study design examining BDNF rs6265 polymorphism
Assessment of motor progression and cognitive profiles
Focused on a Korean population
Identified variations in motor symptom progression linked to BDNF polymorphism
Differences in cognitive profiles associated with the BDNF variants
Suggests BDNF may play a role in modifying Parkinson's disease progression
Abstract
The differences in myocardial denervation at diagnosis, cognitive profiles, and motor progression might suggest a potential modulatory role of BDNF polymorphism in PD progression in the Korean population.