Analyses of the Effects of Wild‐Type TDP‐43 Overexpression in Oxytocin Neurons in Mice

Key Points

• This research aims to evaluate the effects of TDP-43 overexpression in oxytocin neurons on cell population and behavior in mice.
• Selective overexpression of TDP-43 conducted using AAV in oxytocin neurons
• Comparison made with uninjected mice
• Analysis of oxytocin-immunopositive cell counts
• TDP-43 overexpression leads to a decrease in oxytocin-immunopositive cells
• No significant behavioral or metabolic changes observed in mice due to the overexpression