Exploring the effects of renal and cardiac functions on the pharmacokinetics of vancomycin in patients undergoing cardiac surgery: a population pharmacokinetic analysis

Key Points

• This research aims to analyze how renal and cardiac functions influence vancomycin pharmacokinetics in patients undergoing cardiac surgery.
• Established a population pharmacokinetic model for vancomycin
• Analyzed data from patients undergoing cardiac surgery
• Considered both renal and cardiac function in the model
• Renal function positively influences vancomycin clearance
• Cardiac function also impacts vancomycin pharmacokinetics
• Findings suggest need for individualized dosing in cardiac surgery patients