Baicalin Attenuates Ferroptosis after Subarachnoid Hemorrhage via the PI3K/AKT/GPX4 and NLRP3 Axis.

Key Points

• The research aims to explore how baicalin impacts ferroptosis after subarachnoid hemorrhage.
• Investigate the effect of baicalin on ferroptosis in experimental models of subarachnoid hemorrhage.
• Analyze the involvement of the PI3K/AKT pathway in this process.
• Evaluate the role of NLRP3 in conjunction with GPX4 in ferroptosis modulation.
• Baicalin significantly reduces indicators of ferroptosis after subarachnoid hemorrhage.
• Activation of the PI3K/AKT pathway is observed with baicalin treatment.
• NLRP3 and GPX4 levels are effectively regulated, supporting the protective role of baicalin.