What question did this study set out to answer?

The study aimed to evaluate treatment patterns and survival outcomes in retroperitoneal sarcoma patients, particularly focusing on those receiving eribulin therapy.

January 24, 2026

A Japanese Multicenter Database Study of Retroperitoneal Sarcoma: Outcomes of Patients Receiving Eribulin Therapy

Key Points

The study aimed to evaluate treatment patterns and survival outcomes in retroperitoneal sarcoma patients, particularly focusing on those receiving eribulin therapy.
Analyzed clinicopathologic data from 118 patients with retroperitoneal sarcoma diagnosed between 2000 and 2025
Examined surgical resection rates, recurrence-free survival, and overall survival
Identified histologic subtypes and correlated various markers with prognosis
86% of patients underwent surgical resection with a median recurrence-free survival of 20 months
Overall survival median was 9.2 years
In patients receiving eribulin, the complete response rate was 4.3%, partial response 26%, and stable disease 35%
Adverse events included decreased neutrophil count (40%) and peripheral neuropathy (30%)

Abstract

ABSTRACT Aim Clinical evidence on disease characteristics and outcomes of retroperitoneal sarcoma (RPS) remains limited. Although eribulin was approved for soft tissue sarcomas in Japan in 2016, real‐world data on its use for advanced RPS are scarce. We investigated treatment patterns and survival outcomes of patients with RPS, with a particular focus on those receiving eribulin. Methods The database included 118 patients pathologically diagnosed with RPS between January 2000 and August 2025. Clinicopathologic data, including inflammation/nutrition markers and survival outcomes, were analyzed. Results Among them, 102 (86%) underwent surgical resection of the primary tumor, with a median recurrence‐free survival of 20 months and a median overall survival of 9.2 years. Well‐differentiated liposarcoma, dedifferentiated liposarcoma, leiomyosarcoma, and undifferentiated pleomorphic sarcoma were the most frequent histologic subtypes. Non‐well‐differentiated liposarcoma histology, Stage IIIA−IIIB, lower C‐reactive protein–albumin–lymphocyte index, and higher modified neutrophil–platelet score were associated with poor postoperative prognosis. Of 44 patients with unresectable RPS who received systemic therapy, 23 (52%) were treated with eribulin. In this group, complete response, partial response, and stable disease rates were 4.3%, 26%, and 35%, respectively. The most common adverse events were decreased neutrophil count (40%), peripheral neuropathy (30%), and dysgeusia (20%). Multivariate analysis showed that non‐use of eribulin and undifferentiated pleomorphic sarcoma were independently associated with worse survival in unresectable disease. Conclusion We separately described outcomes and treatment patterns of patients with resectable and unresectable RPS. Our findings suggest that eribulin should be considered a treatment option for unresectable RPS in clinical practice.

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