Triple-negative breast cancer (TNBC) is a type of breast cancer that has a high rate of growth and metastasis. In this study, the liquid fermentation product (EX-9) of Penicillium griseofulvum, an endophytic fungus derived from the medicinal plant Delphinium grandiflorum L., has exhibited significant anti-cancer activity against TNBC. We investigated the therapeutic effects and potential mechanisms of EX-9 on TNBC both in vivo and in vitro. Our findings demonstrated that EX-9 exhibited remarkable efficacy against TNBC both in vivo and in vitro, while showing negligible toxicity. The potential mechanism for its anti-TNBC effect involved the inhibition of the PI3K/Akt signaling pathway. Additionally, we employed liquid chromatography-mass spectrometry (LC-MS) technology and network pharmacology methods to uncover the potential pharmacological substance basis of EX-9 in combating TNBC.
Li et al. (Fri,) studied this question.