These findings suggest that p-tau217 could play a role in MBI, particularly in the impulse dyscontrol and emotion dysregulation domains, neuropsychiatric symptoms which have been previously linked to Alzheimer's disease. However, overall cognitive status emerged as the strongest predictor of these behavioral symptoms in older adults. Further research is warranted to clarify how p-tau217 levels and cognitive decline interact to influence the risk and progression of MBI.
Real et al. (Mon,) studied this question.