Gadoxetic Acid–enhanced MRI Radiomics Features of Tumor Margins for Predicting High-Risk Solitary Hepatocellular Carcinoma Aggressiveness and Prognosis

Key Points

• The study aims to develop a radiomics model using gadoxetic acid–enhanced MRI to predict aggressiveness and prognosis of solitary hepatocellular carcinoma.
• Utilized gadoxetic acid–enhanced MRI to capture tumor margin characteristics.
• Developed a radiomics model based on MRI data.
• Correlated findings with RNA sequencing and histopathologic analyses.
• The model demonstrates strong predictive performance for microvascular invasion and prognosis.
• Findings were validated across different cohorts.
• Biological support was provided by genomic and histopathologic data.