Nuciferine Prevents Obesity by Inhibiting Macrophage Inflammation Involving LGALS3, CTSB, and RBP4 Genes Based on an Integrative Analysis of Adipose Tissue Transcriptomics and Network Pharmacology.

Key Points

• The aim is to explore how nuciferine affects inflammation-related genes in adipose tissue to combat obesity.
• Conducted an integrative analysis of adipose tissue transcriptomics
• Analyzed the roles of LGALS3, CTSB, and RBP4 genes
• Assessed mRNA levels related to macrophage inflammation
• Nuciferine significantly reduced mRNA levels of LGALS3, CTSB, and RBP4
• Inhibition of these genes correlated with decreased adipose tissue inflammation
• Suggests a potential role of nuciferine in obesity prevention