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This research aims to investigate how fucosylation affects the homing and longevity of CD34⁺ hematopoietic stem cells (HSCs).

February 2, 2026BMC Cancer0 citationsOpen Access

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Fucosylation enhances CD34⁺ hematopoietic stem cell homing and longevity via E-selectin–mediated adhesion and signaling

AAAsma S. Al-AmoodiKing Abdullah University of Science and Technology AAArwa AlghuneimKing Faisal Specialist Hospital & Research Centre JMJana S. MalkiKing Abdullah University of Science and Technology

Key Points

This research aims to investigate how fucosylation affects the homing and longevity of CD34⁺ hematopoietic stem cells (HSCs).
Examined the role of fucosylation in E-selectin interactions and adhesion of HSCs.
Analyzed migration patterns of HSCs influenced by fucosylation.
Studied intracellular signaling pathways activated by E-selectin in HSCs.
Fucosylation significantly enhances the adhesion of HSCs to E-selectin.
Migratory efficiency of HSCs is improved with increased fucosylation.
HSC longevity is positively correlated with enhanced E-selectin signaling.

Abstract

Fucosylation critically modulates E-selectin interactions, migration, and intracellular signaling in HSCs. These findings highlight glycoengineering as a promising strategy to enhance HSC transplantation outcomes in cancer therapy.

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Fucosylation enhances CD34⁺ hematopoietic stem cell homing and longevity via E-selectin–mediated adhesion and signaling

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