Morphologic and immunophenotypic characterization of lymphocytosis following BCMAtargeted CAR-T cell therapy in relapsed/refractory multiple myeloma

Key Points

• This research aims to characterize the morphology and immune profile of lymphocytes in response to CAR-T cell therapy in multiple myeloma patients.
• Conducted a detailed morphologic assessment of lymphocytes post-treatment
• Performed immunophenotyping to identify lymphocyte types
• Analyzed changes in lymphocyte characteristics over time post-therapy
• Identified significant increases in lymphocyte counts following therapy
• Observed distinct immunophenotypic changes indicative of an effective immune response
• Characterized specific lymphocyte subpopulations associated with therapy outcomes