The coronavirus disease 2019 (COVID-19) pandemic has brought forth with it many challenges for the management and treatment of patients with hematological malignancies. Amongst the hematological malignancies in young to middle-aged adults Acute Myeloid Leukemia (AML) is one of the commonest malignancies, however occurring de-novo with COVID-19RTPCR confirmed cases, is a rare presentation to the best of our knowledge. This concomitant appearance of AML with COVID-19without any previous history is rare. We are presenting four cases of COVID-19with coexistent AML. The diagnosis was established with the correlation of flow cytometry, bone marrow examination, and radiology. Though it is known that patients with concomitant infection of leukemia and COVID-19 develop severe disease and complications, the treatment strategies should be formulated at the early onset of the infection to minimize the mortality and morbidity associated with both these conditions. Key words: COVID-19, AML, young adults, mortality.
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