Advances in organelle-targeted photosensitizer-mediated pyroptosis for photodynamic tumor therapy: overcoming immunological limitations | Synapse
February 11, 2026
Advances in organelle-targeted photosensitizer-mediated pyroptosis for photodynamic tumor therapy: overcoming immunological limitations
Key Points
The review focuses on improving tumor treatment by using organelle-targeted methods to induce pyroptosis through photodynamic therapy.
Review of current literature on organelle-targeted therapies and pyroptosis mechanisms.
Analysis of immunological responses to photodynamic therapy in tumors.
Evaluation of strategies to enhance treatment efficacy through targeted approaches.
Organelle-targeted therapies show potential in activating pyroptosis, leading to enhanced tumor response.
There is a significant improvement in overcoming immunosuppression associated with tumors using these methods.
Abstract
This review highlights organelle-targeted pyroptosis-enhanced PDT as a promising strategy to overcome tumor immunosuppression and clinical limitations.