What question did this study set out to answer?

To explore the role of micrornas as therapeutic agents in targeting breast cancer stem cells (BCSCs).

February 12, 2026Open Access

Therapeutic Potential of MicroRNAs in Targeting Breast Cancer Stem Cells: A Systematic Review

Key Points

To explore the role of micrornas as therapeutic agents in targeting breast cancer stem cells (BCSCs).
Conducted a systematic review of existing literature on micrornas and BCSCs.
Analyzed the regulatory effects of micrornas on proliferation, resistance, and metastasis.
Identified gaps in current experimental frameworks and in vivo studies.
Micrornas demonstrate significant potential to regulate BCSC behaviour.
Need for standardized frameworks in experimental designs was emphasized.
Current knowledge gaps highlight the necessity for deeper mechanistic insights.

Abstract

miRNAs represent promising therapeutic candidates for targeting BCSCs through coordinated regulation of proliferation, resistance, and metastatic behaviour. However, the translational advancement of miRNA-based strategies requires more standardized experimental frameworks, expanded in vivo studies, and deeper mechanistic investigation to ensure safety and efficacy across breast cancer subtypes.

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