Impact of antibiotics on survival outcomes and risk of gastritis/colitis in advanced-stage melanoma patients receiving immune checkpoint inhibitor therapy

Key Points

• The aim is to explore how antibiotic use affects survival and gastrointestinal risks in advanced melanoma patients on immune therapy.
• Analyzed the timing and spectrum of antibiotic use in patients receiving immune checkpoint inhibitors.
• Compared survival rates and incidence of gastritis/colitis between those on antibiotics and those who were not.
• Examined cases with specific focus on antibiotics lacking anaerobic coverage.
• Patients receiving antibiotics during treatment showed improved survival rates.
• Those with antibiotics that did not cover anaerobic bacteria had better outcomes than those with broader coverage.
• A notable correlation exists between antibiotic use timing and gastrointestinal complication rates.