Abstract This article evaluates the effect of silver nanoparticle (SNP), itraconazole, and a combination of the two agents on the adherence of Candida albicans, Streptococcus mutans, and Enterococcus faecalis on acrylic and silicone tissue conditioners Acrylic-based tissue conditioners (ABTCs) and silicon-based tissue conditioners (SBTCs) were treated with SNPs, and their inhibitory effect on biofilm formation was tested against C. albicans, S. mutans, and E. faecalis. The amount of biofilm formed was assessed by the enzyme-linked immunosorbent assay reader. Analysis of variance tests were used for inter- and intragroup comparison. Tukey post hoc test was used for comparison between the tissue conditioners, microorganisms, and culture medium. Pellets of ABTC and SBTC treated with SNPs were studied for adherence of C. albicans, S. mutans, and E. faecalis. A statistically significant decrease in adherence of all three microbes was observed. SNP and itraconazole are effective antifungal and antibacterial agents that can potentially decrease microbial colonization of C. albicans, S. mutans, and E. faecalis on tissue conditioners. SNP and itraconazole, when used, will decrease biofilm formation, which will not only improve the overall health of the oral cavity but also prevent denture stomatitis and diseases associated with poor oral hygiene protocols.
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