What question did this study set out to answer?

The aim is to compare corneal biomechanical parameters between normal corneas and those after keratoplasty using CORVIS-ST.

February 12, 2026Open Access

Corneal biomechanics with CORVIS-ST in post-keratoplasty corneas

Key Points

The aim is to compare corneal biomechanical parameters between normal corneas and those after keratoplasty using CORVIS-ST.
Cross-sectional observational study with 150 normal corneas and 150 post-keratoplasty corneas.
Data collected on demographic details, visual acuity, refraction, axial length, and corneal topography.
CORVIS-ST imaging parameters were recorded for analysis.
12 out of 18 evaluated parameters showed significant differences between post-keratoplasty and normal corneas.
Post-keratoplasty corneas displayed reduced biomechanical strength compared to normal corneas.
Corneal biomechanics were closest to normal in the DSAEK subgroup, while DALK showed lower strength than PK.

Abstract

Abstract Purpose: Comparative evaluation of the corneal biomechanical parameters by the dynamic corneal response imaging with CORVIS-ST ST in normal and post-keratoplasty eyes. Methods: Cross-sectional observational study of CORVIS-ST imaging of 150 normal corneas and 150 post-keratoplasty corneas was done to evaluate corneal biomechanics of normal Asian-Indian corneas and post-keratoplasty corneas. Data on demographic details, postoperative period, visual acuity (UCVA, BCVA) (logmar units), refraction, axial length (D), corneal topography Scheimpflug’s imaging with Pentacam Anterior-K1(AK1), Anterior-K2 (AK2), Posterior-K1(PK1), PosteriorK2(PK2), Mean keratometry (Kmean), Keratometry maximum (Kmax), Q-value, D-value, Thinnest pachymetry (TP), Corneal elevation [anterior (CE ant) and posterior (CE post), CORVIS-ST imaging (bIOP, 1 st and 2 nd Appl time HCT, 1 st Appl length, DA, TBI, CBI, HC rad, Vel in and out, DA ratio, IR, Inv CR, SSI, SPA1, ARTh) were recorded. Results: Comparative evaluation of CORVIS-ST in 150 normal corneas mean age 32.54 ± 10 (9–68) years and 150 post-keratoplasty corneas mean age 35.14 ± 16.96 (8–72) years; PK (58), DSAEK (29), DALK (58), HALK (8), and SALK (3) noted 18 parameters (bIOP, 1 st and 2 nd Appl time HCT, 1 st Appl length, DA, TBI, CBI, HC rad, Vel in and out, DA ratio, IR, Inv CR, SSI, SPA1, ARTh) and showed that 12 of these were statistically different in post-keratoplasty corneas. Parameters of DA, TBI, CBI, IR, and Inv CR were higher, whereas HC rad, SSI, SPA1, and ARTh showed significantly lesser values in post-keratoplasty corneas as compared to normal corneas. Subgroup analysis (PK, DSAEK, DALK, HALK) showed eyes that underwent DSAEK had biomechanical values closest to that of normal corneas. Post-DALK in comparison to post-PK corneas showed significantly higher values in CBI and IR, and lower values in HC rad, SSI, and ARTh (0.87 ± 0.17, 9.9 ± 3.5, 0.85 ± 0.25, 190.92 ± 119.06 and 0.71 ± 0.25, 8.19 ± 1.92, 1.02 ± 0.38, and 340.90 ± 178.37, respectively). Correlational analysis showed significant mild positive correlation of CBI with corneal curvature in normal and post-PK corneas ( P = 0.004 and 0.040, respectively). Conclusion: Post-keratoplasty corneas were seen to have lesser biomechanical strength as compared to normal corneas. Post-DSAEK corneas had a better biomechanical strength than other groups and closest biomechanics to normal corneas. Post-DALK in comparison to post-PK corneas showed a lower biomechanical strength in our study.

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Cite This Study

Ghosh et al. (Wed,) studied this question.

synapsesocial.com/papers/698d6eeb5be6419ac0d54dbe https://doi.org/https://doi.org/10.4103/ijo.ijo_1029_25

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