What question did this study set out to answer?

To explore the role of SOX8 in promoting enzalutamide resistance in prostate cancer through lipid metabolic changes.

February 13, 2026Open Access

SOX8/CPT2 axis regulates lipid metabolism to support enzalutamide resistance in prostate cancer

SLSongsong LiuAnhui Medical University DZDingyong ZhangAnhui Medical University CJChao JiangAgency for Science, Technology and Research

Key Points

To explore the role of SOX8 in promoting enzalutamide resistance in prostate cancer through lipid metabolic changes.
Assessment of SOX8 expression levels in prostate cancer cells
Analysis of lipid metabolism pathways
Evaluation of enzalutamide resistance mechanisms
High SOX8 levels correlate with increased enzalutamide resistance in prostate cancer cells
Activation of the SOX8/CPT2 axis leads to lipid metabolic reprogramming
Targeting SOX8 may provide a new therapeutic approach to combat resistance

Abstract

High SOX8 expression promotes EnzR in PCa, suggesting SOX8 as a potential therapeutic target. Our findings demonstrate that SOX8 drives EnzR by activating the SOX8/CPT2 axis, thereby inducing lipid metabolic reprogramming in PCa cells.

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