What question did this study set out to answer?

The study aims to investigate the effects of washed microbiota transplantation on menstrual health and mental well-being in women of childbearing age.

February 14, 2026Open Access

The influence of washed microbiota transplantation on menstruation in female patients of childbearing age

Key Points

The study aims to investigate the effects of washed microbiota transplantation on menstrual health and mental well-being in women of childbearing age.
Collected data from female patients receiving WMT from February 2023 to February 2025.
Conducted comparative analyses of life quality (SF-36), depression (SDS), and anxiety (SAS) scores before and after WMT.
Analyzed gut microbiota changes using 16S rRNA gene sequencing.
WMT significantly improved SF-36 scores for general health, mental health, and vitality.
Depression and anxiety scores decreased significantly post-WMT.
WMT enhanced gut microbiota diversity with increased abundances of Dialister, Bifidobacterium, and others.

Abstract

Background and aims Menstrual disorders are closely related to the disorder of gut microbiota. This study aims to explore the impact of Washed microbiota transplantation (WMT) on the quality of life, depression and anxiety scale scores, and menstrual conditions of female patients of childbearing age. Methods The data of female patients of childbearing age who received WMT at the First Affiliated Hospital of Guangdong Pharmaceutical University from February 2023 to February 2025 were collected. A comparative analysis was conducted on the effects of SF-36, SDS, SAS and menstrual conditions in female patients of childbearing age before and after WMT treatment. The changes of gut microbiota before and after WMT were analyzed by 16S rRNA gene sequencing. Results A total of 23 female patients of childbearing age were included in this study. WMT significantly improved the scores of GH, SF, MH, RE and VT in SF-36 of female patients of childbearing age and significantly reduced the scores of SDS and SAS (P 0.05). The MDQ score was negatively correlated with the PF, BP, GH, VT, RE and MH scores in SF-36, and positively correlated with the SDS and SAS scores (P 0.05). WMT enhanced the α diversity of gut microbiota in female patients of childbearing age, and the Chao1 and Shannon indices were statistically significant (P 0.05). At the same time, the relative abundance of Dialister , Bifidobacterium , Faecalibacterium , Roseburia and Fusobacterium increases. The relative abundances of Bacteroides , Agathobacter , Prevotella , Escherichia-Shigella and Ruminococcus decreased. Conclusions WMT treatment can effectively improve the quality of life score of female patients of childbearing age and reduce the scores of depression and anxiety scales. WMT can increase the diversity and abundance of gut microbiota in female patients of childbearing age and improve menstrual conditions, which provides new ideas for future clinical treatment.

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Cite This Study

Wu et al. (Wed,) studied this question.

synapsesocial.com/papers/699010382ccff479cfe56cce https://doi.org/https://doi.org/10.3389/fendo.2026.1715020

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