Acute 30-min simulated 5000 m hypobaric exposure in healthy male pilots caused transient increases in HR (80.0 to 91.9 bpm) and BP, and decreased SpO2 (98.4% to 77.7%) (all p<0.001).
Observational (n=75)
Does simulated 5000 m hypobaric exposure alter heart rate, blood pressure, and SpO2 in healthy male Vietnamese pilots?
Acute 5000 m hypobaric hypoxia causes transient, safe, and reproducible tachycardia, hypertension, and hypoxemia in healthy male pilots.
p-value: p=<0.001
Abstract This study was motivated by the limited high‐altitude physiology data available for Asian military aviators, especially in Vietnam. To characterize acute heart rate (HR), blood pressure (BP), and oxygen saturation (SpO 2 ) responses in healthy Vietnamese pilots during simulated 5000 m hypobaric exposure. Seventy‐five healthy male military pilots underwent 30‐min exposure in a hypobaric chamber simulating 5000 m altitude. HR, systolic/diastolic BP (SBP/DBP), and SpO 2 were recorded at baseline (0 m), peak altitude, and post‐exposure. HR increased from 80.0 ± 9.0 to 91.9 ± 11.0 bpm, SBP/DBP rose by 10.4/6.5 mmHg, and SpO 2 decreased from 98.4 ± 1.0% to 77.7 ± 6.0% (all p < 0.001). All changes were transient, returning to baseline within 5 min after exposure, and no adverse events occurred. Higher baseline HR and older age predicted smaller HR increases. Acute 5000 m hypobaric hypoxia caused transient tachycardia, hypertension, and hypoxemia. Response variability correlated with baseline hemodynamic status and age. This safe, reproducible model can serve as a noninvasive cardiovascular stress test in clinical and aerospace medicine.
Thanh et al. (Sun,) conducted a observational in Healthy (n=75). Simulated 5000 m hypobaric exposure vs. Baseline (0 m) was evaluated on Acute heart rate (HR), blood pressure (BP), and oxygen saturation (SpO2) responses (p=<0.001). Acute 30-min simulated 5000 m hypobaric exposure in healthy male pilots caused transient increases in HR (80.0 to 91.9 bpm) and BP, and decreased SpO2 (98.4% to 77.7%) (all p<0.001).