Artesunate ameliorates experimental autoimmune uveitis by inhibiting the LCN2-STAT3 axis and suppressing microglial activation

Key Points

• The study aims to explore how artesunate affects experimental autoimmune uveitis.
• Examined the effects of artesunate on experimental autoimmune uveitis (EAU) models.
• Analyzed the inhibition of the LCN2-STAT3 signaling pathway.
• Assessed the impact on microglial and Th17 cell activation.
• Artesunate significantly reduced the severity of experimental autoimmune uveitis.
• Inhibition of the LCN2-STAT3 axis was observed.
• Microglial and Th17 cell activation was suppressed.