Comparison of Low and High Dose Clonidine for Infants Admitted to the Neonatal Intensive Care Unit. | Synapse
February 14, 2026Open Access
Comparison of Low and High Dose Clonidine for Infants Admitted to the Neonatal Intensive Care Unit.
Key Points
This research investigates the effectiveness of low dose clonidine (LDC) compared to high dose clonidine (HDC) in managing symptoms in NICU infants.
Observational study conducted in a neonatal intensive care unit
Comparison of low and high doses of clonidine
Assessment of outcomes including pain, agitation, and opioid withdrawal
Low dose clonidine may be as effective as high dose clonidine in managing symptoms
Similar effectiveness observed for pain and agitation treatment
No significant difference in outcomes between LDC and HDC
Abstract
Our observational study suggests that starting with LDC may be as effective as HDC in treating pain, agitation, and opioid withdrawal in infants admitted to the NICU.