Monthly Biological Variation of Five Lung Cancer Markers in Healthy Older Individuals: Evidence from Combined Prospective Cohort and Real-World Data Analyses

Key Points

• The research aims to establish a comprehensive database of biological variation for lung cancer biomarkers in elderly Asians.
• Combined prospective cohort and real-world data analyses
• Monthly monitoring of five lung cancer biomarkers
• Focus on healthy older individuals
• Stable monthly variation of biomarkers was identified
• Personalized reference control values (RCVs) could enhance clinical interpretation
• Findings enable earlier therapeutic interventions for aging individuals