Abstract Introduction: Contralateral breast symmetrization by reduction mammaplasy has been incorporated into oncoplastic surgery as a way of improving aesthetic outcomes and body image perceptions among women undergoing breast-conserving treatment for breast cancer. However, the actual impact of this approach to contribute effectively to women’s aesthetic satisfaction and self-image remains unclear. Objective: To evaluate whether immediate contralateral breast symmetrization is associated with greater satisfaction with self-image in women treated with breast-conserving surgery for breast cancer. Method: This cross-sectional study employed an approach involving retrospective clinical- epidemiological data collection and face-to-face application of the Body Dysmorphic Disorder Examination (BDDE) questionnaire, which has been validated in Portuguese. All consecutive women who underwent breast-conserving surgery either with or without contralateral symmetrization, performed by the same surgical team between 2008 and 2017 in a public hospital in Brazil, were included. The participants were divided into two groups: the control group (i.e., the CG, which included participants who underwent only breast-conserving surgery) and the study group (i.e., the SG, which included participants who underwent breast-conserving surgery with immediate contralateral symmetrization). The BDDE scores and aesthetic perceptions of participants in these two groups were compared after 12 months from the end of oncological treatment. Results: A total of 57 patients were evaluated, including 22 in the CG and 35 in the SG. Most participants in both groups (14 in the CG and 20 in the SG) reported satisfaction with the appearance of their breasts in the postoperative period, and no statistically significant differences were observed in this context. Only one patient obtained a score that suggested the presence of body dysmorphic disorder. Conclusion: Immediate contralateral symmetrization was not associated with increased body satisfaction among participants in this research. These findings suggest that this approach should be applied in a judicious and individualized manner; in addition, further studies are needed to better define its impact on patients’ quality of life more effectively. Citation Format: A. C. Cubero, D. I. Cubero, C. C. Mazzei, F. C. Sandoval, J. J. Romano, I. T. Sant’Anna, L. A. Sousa. The impact of immediate contralateral breast symmetrization on body satisfaction among breast cancer survivors abstract. In: Proceedings of the San Antonio Breast Cancer Symposium 2025; 2025 Dec 9-12; San Antonio, TX. Philadelphia (PA): AACR; Clin Cancer Res 2026;32(4 Suppl):Abstract nr PS5-12-27.
Cubero et al. (Tue,) studied this question.