Smart pH-responsive magnetic iron oxide nanoflower–chitosan nanogels for controlled drug delivery in cancer therapy

Key Points

• Identify optimal crosslinking strategies for creating pH-responsive drug delivery nanogels.
• Systematic comparison of crosslinking agents: NaOH, tripolyphosphate, glutaraldehyde.
• Assessment of colloidal stability, drug release profiles, and particle size.
• Evaluation of suitability for intratumoral injection.
• Identified optimal crosslinking conditions for colloidal stability.
• Demonstrated pH-responsive drug release characteristics.
• Achieved suitable size for effective intratumoral delivery.