What question did this study set out to answer?

This study aims to analyze the clinical and epidemiologic characteristics of inflammatory breast cancer cases over a 20-year period.

February 19, 2026

Abstract PS5-04-12: Inflammatory breast cancer : Monocentric epidemiologic, anatomiclinical features and therapeutic results about 68 patients treated from 2004 to 2024

Key Points

This study aims to analyze the clinical and epidemiologic characteristics of inflammatory breast cancer cases over a 20-year period.
Conducted a monocentric retrospective analysis of 68 inflammatory breast cancer cases diagnosed as T4d AJCC.
Collected data on patient demographics, tumor characteristics, treatments, and outcomes.
Analyzed the molecular subtypes and treatment responses, including pathologic complete responses.
Out of 2400 breast cancer cases, 68 were identified as inflammatory breast cancer (2.8%).
Median age of patients was 42.2 years, with local symptoms evolving in less than 6 months.
Observed 19% pathologic complete response in operated patients, with varied responses across molecular subtypes.
Overall survival was 87.14 months, varying significantly among subtypes.

Abstract

Abstract Objective: To report the results of a monocentric retrospective serie of inflammatory breast cancers cases observed and treated during a period of 20 years Patients and methods: We collected in a cohort of breast cancers, the cases of inflammatory breast cancer(IBC) subtype diagnosed as T4d AJCC with an evolution of local symptoms in less than 6 months. We analyzed the epidemiologic, anatomic-clinical features, treatments and results. Results: We collected inside a cohort of 2400 breast cancer cases, 68 patients(2.8%), treated for an IBC, having a median age of 42.2 years(27 to 67) with a mean delay of evolution of 5.8 (3 to 6) months. Molecular subtypes are as followed: Luminal= 39/68(58.5%), Her 2 positive 18/69 (26%) and triple negative 11/68(15.5 %). Mean radiological tumor size was 32.5mm(25 to 70mm). Within the 55 patients operated, we observed 10 pathologic complete responses(19%) in 6 cases of luminal B subtype(3 of them her 2+), 3 her 2 positive subtype and 1 triple negative case. We observed 22 relapses with a mean delay of 24 months, msotly metastatic. Nombre de pCr chez les malades opérées =10 (6 luminal , 3 HER2 surexprimé , 1 TN). Overall survival was at 87,14 months, 108 for luminal B subtype, 96,4 for her 2 positive cases and 15.1 months for triple negative cases. Conclusion: Our monocentric serie from Tunisia, reflet’s the epidemiologic and anatomo-clinical features of IBC in our coutry. Patients remain younger than those reported in western countries. We observed a positive trend in terms of survival between patients treated before and after 2010, probably due to the multidisciplinary management and the impact of targeted therapies in her 2 positive cases. Citation Format: M. Boujnah, S. Myriam, A. Haouari, B. Saif, N. Mejri, M. Manai, H. Boussen. Inflammatory breast cancer: Monocentric epidemiologic, anatomiclinical features and therapeutic results about 68 patients treated from 2004 to 2024 abstract. In: Proceedings of the San Antonio Breast Cancer Symposium 2025; 2025 Dec 9-12; San Antonio, TX. Philadelphia (PA): AACR; Clin Cancer Res 2026;32(4 Suppl):Abstract nr PS5-04-12.

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