What question did this study set out to answer?

To assess the impact of ESBL screening on empiric antibiotic selection and appropriateness of therapy.

February 22, 2026

Effect of extended-spectrum β-lactamase screening on empiric antimicrobial selection: a retrospective cohort study

Key Points

To assess the impact of ESBL screening on empiric antibiotic selection and appropriateness of therapy.
Retrospective cohort study design
Data collected on admissions with ESBL screening
Evaluation of empiric antibiotic choices pre- and post-screening
Screening for ESBL affected antibiotic coverage decisions
Results indicated more appropriate empiric therapy choices after screening

Abstract

Aim: To determine whether admission screening for extended-spectrum β-lactamase-producing Enterobacterales (ESBL-E) influences decisions about empiric antibiotic coverage, and whether having screening results leads to more appropriate empiric therapy choices.

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Cite This Study

Bharara et al. (Sun,) studied this question.

synapsesocial.com/papers/699a534bfdaf4e3c1268ee55 https://doi.org/https://doi.org/10.1016/j.pathol.2026.01.314

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