Biological membranes are highly dynamic environments composed of a diverse array of lipids that vary in chemistry and actively participate in cellular functions. The interactions of proteins, nucleic acids, and glycans at the lipid membrane interface are integral to many cellular processes. The interplay between membrane lipids and biomolecules is highly sensitive to their flexibility grade, secondary structure, and biophysical and electrostatic properties. Consequently, the cell membrane interface experiences changes in local lipid distribution and fluctuation in local properties.
Zhang et al. (Sun,) studied this question.