Zero-Trigger Ultrafast Charge-Transfer J-Aggregates via Se/π-directed Assembly Enable Synchronous ROS/Heat Amplification for NIR-II Photoimmunotherapy

Key Points

• The study aims to enhance the performance of phototheranostics through optimized charge-transfer J-aggregates.
• Utilized supramolecular J-aggregation of π-conjugated photosensitizers.
• Implemented a combined approach leveraging photodynamic therapy (PDT) and photothermal therapy (PTT).
• Evaluated the efficiency of ROS generation and heat amplification in the assembly process.
• Achieved synchronous amplification of reactive oxygen species (ROS) and heat during therapy.
• Demonstrated improved efficacy in NIR-II (near-infrared) photoimmunotherapy.
• Showed successful integration of facile assembly with synergistic therapeutic benefits.