What question did this study set out to answer?

To investigate the impact of glioblastoma on perivascular diffusivity and glymphatic function.

February 23, 2026Open Access

Altered perivascular diffusivity in glioblastoma: integrating DTI-ALPS index with radio-pathomic and histopathologic correlates

Key Points

To investigate the impact of glioblastoma on perivascular diffusivity and glymphatic function.
Analysis of DTI-ALPS index in glioblastoma-affected brain hemispheres.
Assessment of volume and cellularity metrics in relation to DTI-ALPS measurements.
Integration of radio-pathomic and histopathologic data.
Correlation analysis between the DTI-ALPS index and other metrics.
Significant reduction in DTI-ALPS index in tumor-affected hemispheres.
Inverse correlation established between DTI-ALPS index and volume metrics.
Inverse correlation between DTI-ALPS index and cellularity metrics.

Abstract

Our findings suggest that GBM-associated perivascular invasion disrupts glymphatic function, as evidenced by a significantly lower DTI-ALPS index in the tumor-affected hemisphere. The inverse correlation between the DTI-ALPS index and both volume and cellularity metrics highlights the extent to which GBM alters perivascular fluid dynamics.

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Cite This Study

Nath et al. (Sat,) studied this question.

synapsesocial.com/papers/699ba05e72792ae9fd86fe8d https://doi.org/https://doi.org/10.1007/s11060-026-05458-x

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