Secondary poor graft function after autologous stem cell transplantation in multiple myeloma: a case-based expert review and successful rescue with secondary autologous stem cell infusion.

Key Points

• The review aims to explore the causes and solutions for secondary poor graft function after autologous stem cell transplantation in multiple myeloma.
• Expert analysis of case reports on secondary PGF after Auto-HSCT.
• Identification of factors contributing to PGF and assessment of potential interventions.
• Evaluation of the efficacy of secondary autologous PBSC infusion as a rescue strategy.
• Identified multiple factors causing secondary poor graft function, including graft quality issues and therapy exposure.
• Early unpreconditioned autologous PBSC boost found to be safe and feasible.
• Strategic banking of PBSC identified as crucial for preventing life-threatening graft failures.