Enantioselective Access to Chiral Phosphonothioates via Iridium-Catalyzed Asymmetric Allylic Substitution

Key Points

• To establish an effective method for synthesizing chiral phosphonothioates using iridium catalysis.
• Developed an iridium-catalyzed asymmetric allylic substitution protocol.
• Conducted reactions under mild conditions to ensure functional compatibility.
• Evaluated the efficiency of the protocol in generating branched derivatives.
• Successfully synthesized various branched allylic phosphonothioates.
• Demonstrated high enantioselectivity in the reactions.
• Showed compatibility with multiple functional groups, enhancing versatility.