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This review examines the role of the DNA damage response pathway in regulating the nuclear envelope.

February 26, 2026Open Access

Roles of DNA Damage Response Pathway in the Regulation of the Nuclear Envelope

Key Points

This review examines the role of the DNA damage response pathway in regulating the nuclear envelope.
Literature review of studies related to DNA damage and nuclear envelope.
Focus on the actions of ATR within the DNA damage response pathway.
Analysis of the impact of nuclear envelope rupture on macromolecular exchange.
Findings indicate that DNA damage can lead to nuclear envelope rupture.
ATR is identified as a critical factor in mediating these effects on the nuclear envelope.
The review suggests a bidirectional relationship between DNA damage and nuclear envelope integrity.

Abstract

The nuclear envelope (NE) functions as a barrier between the cytoplasm and nucleus. Over the past decade, NE has revealed unexpectedly divergent structural alterations. NE rupture triggers the uncontrollable exchange of macromolecules across the NE and potentially causes DNA damage. Conversely, a recent study demonstrated that DNA damage induces NE rupture and that one of the major kinases in the DNA damage response (DDR) pathway, ataxia telangiectasia and Rad3-related protein, ATR, is a key molecule in these events. Here, we review the role of the DDR pathway in NE regulation, with a focus mainly on ATR.

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