What does this research mean for the field?

A same-session hybrid approach combining open resection and laser interstitial thermal therapy (LITT) safely achieves extensive cytoreduction in multifocal glioblastoma. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research focuses on the effectiveness of a hybrid surgical approach for treating multifocal glioblastoma.

February 26, 2026

Same-session hybrid surgery for multifocal glioblastoma: integrating open resection with laser interstitial thermal therapy. Illustrative cases

Key Points

This research focuses on the effectiveness of a hybrid surgical approach for treating multifocal glioblastoma.
Implemented a same-session hybrid surgical strategy combining open resection with laser interstitial thermal therapy (LITT).
Utilized real-time MRI thermography during procedures to monitor and ensure safe ablation.
Analyzed illustrative cases to demonstrate procedure safety and effectiveness.
Achieved extensive cytoreduction in multifocal glioblastoma cases.
Eliminated the need for multiple craniotomies, reducing patient risk.
Facilitated faster initiation of adjuvant therapy after surgery.

Abstract

A hybrid approach combining resection and LITT can safely achieve extensive cytoreduction in multifocal GBM while avoiding multiple craniotomies. Same-session strategies eliminate repeat anesthesia exposure and expedite adjuvant therapy initiation. Real-time MRI thermography allows safe ablation of eloquently located lesions. https://thejns.org/doi/10.3171/CASE25940.

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