Objective The aim is to systematically evaluate the clinical efficacy of Traditional Chinese Medicine (TCM) in the treatment of cancer related anemia (CRA), and to provide higher quality evidence-based medical evidence for the treatment of CRA with TCM. Methods Pubmed, Embase, Cochrane library, Scopus, Web of Science, China National Knowledge Infrastructure (CNKI), China Biology Medicine Disk (CBM) and WanFang were searched for the literature on TCM treatment of CRA included in the databases from the establishment of the databases to December 2025. Meta-analysis was performed using ReVman5.3 software. Results 6,201 relevant literatures were retrieved. According to inclusion and exclusion criteria, a total of 58 literatures were included, with a total of 4,308 patients, including 2,157 patients in the treatment group and 2,151 patients in the control group. The treatment group was better than the control group in improving hemoglobin level, clinical efficacy, KPS score, TCM syndrome efficacy, TCM Syndrome Score, immune function and red blood cell count, the difference was statistically significant ( P 0.05). By drawing a funnel figure of hemoglobin levels, it was found that the left and right sides of the funnel figure were basically symmetrical, indicating that the publication bias of this study was low. It can be considered that TCM treatment can significantly improve hemoglobin and improve the anemia of patients. Conclusion Traditional Chinese Medicine can significantly improve CRA, enhance TCM syndrome and immune function, and improve patients’ quality of life. Clinical Trial Registration https://www.chictr.org.cn , identifier ChiCTR2300077699.
Li et al. (Tue,) studied this question.