Iron-Catalyzed Radical-Mediated 1,3-Azidoalkylation of Bicyclo1.1.0butanes: Access to 1,1,3,3-Tetrasubstituted Cyclobutanes via Strain Release

Key Points

• To explore iron-catalyzed radical-mediated 1,3-azidoalkylation of bicyclo[1.1.0]butanes and synthesize tetrasubstituted cyclobutanes.
• Employ iron-catalyzed proton-coupled electron transfer to activate diazo compounds.
• Generate alkyl radicals for addition to bicyclo[1.1.0]butanes.
• Conduct azide transfer followed by characterization of cyclobutane products.
• Successfully synthesized 1,1,3,3-tetrasubstituted cyclobutanes with good yields.
• Achieved high stereoselectivity in the cyclobutane products.
• Demonstrated a new pathway for cyclobutane synthesis using radical-mediated processes.