What question did this study set out to answer?

February 27, 2026Open Access

Development of a Complex Biofeedback-Based Intervention to Improve Methotrexate Adherence in Rheumatoid Arthritis: A COM-B Model Informed Qualitative Study

Key Points

The aim is to understand factors affecting methotrexate adherence in rheumatoid arthritis patients and develop a related intervention.
Conducted 1:1 semi-structured telephone interviews with RA patients
Developed an interview guide based on the COM-B model and Theoretical Domains Framework
Inductively analyzed transcripts to identify themes related to adherence
Identified five themes influencing methotrexate adherence
Themes included knowledge, motivators and barriers, healthcare approach, habits, and biochemical adherence tests
Findings suggest specific behaviour change techniques can improve adherence based on identified capabilities and motivations

Abstract

Introduction: Methotrexate (MTX) is one of the first-line treatments for Rheumatoid arthritis (RA) but sub-optimal adherence to MTX is common. Adherence can be challenging to detect in the clinic but can be assessed objectively using a MTX biochemical adherence test measuring levels of MTX in the blood. However, it remains unknown how to use the results of MTX biochemical adherence tests to improve adherence. COMMIT (development of a COMplex Methotrexate adherence IntervenTion utilising biofeedback) is a qualitative study designed to explore adherence to MTX in RA patients and aid the development of a behaviour change intervention that can be delivered alongside MTX biochemical adherence testing. Methods: Potential participants were identified from the Rheumatoid Arthritis Medications Study (RAMS), a large national study of patients with RA commencing MTX. An interview topic guide was developed using the Capability, Opportunity and Motivation to Behaviour (COM-B) model and the Theoretical Domains Framework (TDF). Consenting participants took part in a 1:1 semi-structured telephone interview. Transcripts were inductively analysed and mapped to themes. Results: Seventeen participants treated with MTX for a mean 3 years (range 3– 20) took part in the semi-structured interviews. Five overarching themes were identified and mapped to behaviour change techniques. Themes included 1. Knowledge of MTX and its impact, 2. Motivators versus barriers for continuation of MTX, 3. The healthcare approach in shaping patient adherence, 4. Creating habits and routines 5. MTX biochemical adherence blood tests and external monitoring of behaviour. Conclusion: This study has identified many of the key facilitators and barriers that influence adherence to methotrexate in RA patients. Through identifying the capabilities, opportunities, and motivations that shape engagement with MTX biochemical adherence testing, we can select targeted behaviour change techniques to address these factors. This theory-driven approach offers a novel pathway to improving uptake of MTX adherence testing. Keywords: biochemical adherence, qualitative research, methotrexate, self-management

Bookmark

View Full Paper

Cite This Study

Shafi et al. (Sun,) studied this question.

synapsesocial.com/papers/69a134fbed1d949a99abe687 https://doi.org/https://doi.org/10.2147/ppa.s548188

Bookmark

View Full Paper