Immunogenicity of induced pluripotent stem cell-derived smooth muscle cells results from a reduction in the expression of indoleamine 2,3 dioxygenase (IDO-1).

Key Points

• This research aims to understand how the expression of IDO-1 affects the immunogenicity of induced pluripotent stem cell-derived smooth muscle cells (iPSC-SMC).
• Analyzed IDO-1 expression levels in iPSC-derived smooth muscle cells.
• Compared immune response modulation between iPSC-SMC and vascular smooth muscle cells (v-SMC).
• Conducted immune phenotyping of iPSC-derivatives for therapeutic context.
• iPSC-SMC showed reduced IDO-1 expression compared to v-SMC.
• Lower IDO-1 expression impaired the ability of iPSC-SMC to modulate immune responses.
• The findings highlight the relevance of immune phenotyping for the use of iPSC-derivatives.