TFAM-Mediated mtDNA Replication is Essential for Developmental Competence of In Vitro Grown Oocytes.

Key Points

• The aim is to investigate the role of TFAM in mtDNA replication and its impact on the developmental abilities of in vitro grown oocytes.
• Analyzed TFAM's role in mitochondrial function
• Assessed mtDNA replication in IVG-derived oocytes
• Evaluated developmental competence of cultured oocytes
• TFAM is essential for proper mtDNA replication
• Oocytes with impaired TFAM show reduced developmental competence
• Enhanced mitochondrial function correlates with improved oocyte development