Comparative evaluation of the short-chain fatty acids formate, propionate, and valerate on intestinal barrier maturation and bone development in neonatal mice

Key Points

• The aim is to evaluate the effects of specific short-chain fatty acids on intestinal maturation and bone development in neonatal mice.
• Neonatal mice were treated with formate, propionate, and valerate.
• Effects on intestinal barrier maturation were assessed.
• Skeletal development was monitored and compared among the different SCFAs.
• All three SCFAs showed positive effects on intestinal barrier function.
• Propionate had the most significant impact on bone development and maturation.
• Valerate and formate also contributed to improved skeletal outcomes but to a lesser extent.