Active bone marrow dose reconstruction in a large-scale cohort study of cancer patients treated with photon radiotherapy.

Key Points

• The aim is to reconstruct active bone marrow dose and relevant metrics to study radiotherapy's effects on cancer.
• Developed an EMR-based approach for dose reconstruction.
• Focused on patients undergoing external beam radiotherapy (EBRT).
• Analyzed dose heterogeneity for improved exposure variables.
• Estimated more informative variables than mean active bone marrow dose.
• Identified the role of radiotherapy in leukemogenesis.
• Results indicate potential health impacts and implications for treatment evaluations.

Abstract