The Indian Medicinal plant Calotropis gigantea leaf extract was incorporated in silver nanoparticle with the added polymeric matrix of PVA and PEG. Thus, Calotropis gigantea was used as capping agent in silver nanocomposite, and hence, a thin film was synthesized by solvent casting method. The morphology of the as-prepared thin film was confirmed by XRD, FESEM and EDAX studies. The presence of functional groups of Calotropis gigantea and silver nanocomposite was well-established in FTIR report. Optical property of as synthesized thin film was confirmed by UV-Vis analysis. Antibacterial studies of the PVA/PEG films comprising AgNPs show a potent antibacterial effect against Gram-negative bacterial strains by Agar-Agar well-diffusion method. Antioxidant activities were carried out through four different assays: DPPH, SOD, NO and H 2 O 2 . Cytotoxic studies were carried out with these synthesized PVA/PEG films containing AgNPs using MTT assay on MCF-7 cells. The synthesized thin film with an IC50 value of 43.29 (μg/ml) will show a promising result in in vitro studies.
Nandhini et al. (Thu,) studied this question.