BRS/The Brain Resilience Study: Cognitive performance on a test of pattern separation is associated with cortical thickness in older adults

Key Points

• This research aims to explore the relationship between cognitive performance on pattern separation tests and cortical thickness related to Alzheimer's disease in older adults.
• Analyzed cognitive performance on pattern separation tests among cognitively normal older adults.
• Measured cortical thickness related to Alzheimer's Disease signature.
• Assessed the association between cognitive performance and cortical thickness.
• Significant association found between cognitive performance on pattern separation and cortical thickness.
• Cortical thickness serves as a potential indicator of underlying neurodegenerative processes.
• Episodic memory impairments were linked with ineffective pattern separation.

Abstract