Trial Design and Objectives for Patients With Prostate Cancer: Recommendations From the Prostate Cancer Working Group 4

Key Points

• The central aim is to update recommendations for prostate cancer trial design to benefit a diverse patient population.
• Review existing recommendations on patient and tumor characterization
• Develop new guidelines for therapy development
• Extend imaging criteria to earlier disease states
• Recommendations reflect a more diverse and heterogeneous patient population
• Guidelines aim to optimize treatment benefits across various cancer stages
• Enhanced focus on earlier intervention in androgen pathway modulator-naïve patients