Lean body weight-indexed oxygen delivery below 292 ml/min/m2 during cardiopulmonary bypass is linked to increased acute kidney injury risk (OR 0.998, p<0.001).
Does lean body mass-adjusted indexed oxygen delivery (DO2i) during cardiopulmonary bypass predict the risk of acute kidney injury in cardiac patients?
Lean body weight-adjusted O2 delivery during cardiopulmonary bypass is an independent risk factor for postoperative acute kidney injury, with a critical minimum threshold of 292 mL/min/m2.
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IntroductionMonitoring indexed oxygen delivery (DO2i) is recommended during cardiopulmonary bypass (CPB) and a predictor of acute kidney injury (AKI). The use of lean body mass-adjusted blood flow rates in obese patients during CPB may provide a valid representation of metabolic demand, however, the risk of AKI with this approach has not been reported. This study aimed to investigate the influence of lean body mass-adjusted DO2i values in the risk of AKI following CPB.MethodsUtilizing the Australian and New Zealand Collaborative Perfusion Registry dataset, 12,811 cardiac patients were divided into 2 groups; non-obese (BMI 30). Obese patients' lean mass was derived from their recalculation to a BMI of 25 and used for the calculation of DO2i. Postoperative AKI was classified using the RIFLE criteria.ResultsIncidence of AKI was higher in the obese compared to non-obese group (15% vs 11%, p 2i was significantly associated with an increased risk of AKI (OR, 0.998; 0.997-0.999, p 2.ConclusionsLean body weight-adjusted O2 delivery remains an independent risk factor for AKI. The critical minimum DO2i threshold of 292 mL/min/m2 is within the range of previously reported values, inferring that lean-based blood flow monitoring may offer a reasonable approach to CPB practice.
Carter et al. (Thu,) reported a other. Lean body weight-indexed oxygen delivery below 292 ml/min/m2 during cardiopulmonary bypass is linked to increased acute kidney injury risk (OR 0.998, p<0.001).